Not equals query is so slow - mysql

Question

I have a query like that:
SELECT * , (
( 1584392725 ) - ( suprayts.time )
) AS timeDiff
FROM (
`suprayts`
)
WHERE `suprayts`.`is_deleted` = '0'
AND `suprayts`.`is_approved` =1
AND `suprayts`.`username` != 'rayben1'
AND `suprayts`.`time` >1584306325
ORDER BY `suprayts`.`is_boosted_by_user` DESC , `suprayts`.`id` ASC
LIMIT 10
This query runs very slow (avg 0.2 seconds), if i delete the following line:
AND `suprayts`.`username` != 'rayben1'
It runs 10x faster. (avg 0.02 secs) How can i speed up this query?
My indexes:
Explain:
My table:
CREATE TABLE IF NOT EXISTS `suprayts` (
`id` int(10) unsigned NOT NULL AUTO_INCREMENT,
`username` varchar(15) CHARACTER SET utf8 NOT NULL,
`question` varchar(70) COLLATE utf8mb4_unicode_ci NOT NULL,
`suprayt_photo` varchar(50) CHARACTER SET utf8 NOT NULL,
`time` int(11) NOT NULL,
`endTime` int(11) NOT NULL,
`datetext` timestamp NOT NULL DEFAULT CURRENT_TIMESTAMP,
`like_count` int(10) unsigned NOT NULL DEFAULT '0',
`dislike_count` int(10) unsigned NOT NULL DEFAULT '0',
`is_approved` bit(1) NOT NULL DEFAULT b'0',
`is_deleted` enum('1','0') CHARACTER SET utf8 NOT NULL DEFAULT '0',
`is_end_notification_sent` bit(1) NOT NULL DEFAULT b'0',
`open_vote` enum('0','1') CHARACTER SET utf8 NOT NULL DEFAULT '1',
`boost` int(11) NOT NULL DEFAULT '0',
`is_boosted_by_user` tinyint(1) NOT NULL DEFAULT '0',
PRIMARY KEY (`id`),
UNIQUE KEY `username_3` (`username`,`suprayt_photo`),
KEY `id` (`id`,`time`,`is_approved`,`is_deleted`),
KEY `username` (`username`,`is_deleted`),
KEY `username_2` (`username`,`datetext`),
KEY `id_2` (`id`,`username`,`time`,`is_approved`,`is_deleted`),
KEY `username_4` (`username`,`time`,`is_approved`,`is_deleted`),
KEY `ix1` (`id`,`time`)
) ENGINE=MyISAM DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci AUTO_INCREMENT=130789 ;

Answer 1

Depending on the SQL pre-compiler if one is being used, or the SQL itself, possible it is sensitive to the order of the query "where" clause not being in DB key order and it is not using the index and instead doing a sequential scan? Just to eliminate the possibility, try putting the WHERE items in the DB index key order.

Answer 2

USE NOT EXISTS
SELECT * , (
( 1584392725 ) - ( suprayts.time )
) AS timeDiff
FROM (
`suprayts`
)
WHERE `suprayts`.`is_deleted` = '0'
AND `suprayts`.`is_approved` =1
AND NOT EXISTS (
SELECT x.no FROM (SELECT 1 AS no) x WHERE `suprayts`.`username` = 'rayben1'
)
AND `suprayts`.`time` >1584306325
ORDER BY `suprayts`.`is_boosted_by_user` DESC , `suprayts`.`id` ASC
LIMIT 10